The Mena Valley forms a natural corridor running from East to West between the towns. Villasana de Mena was declared a town in the 9th century, during the reign of Alphonse VI. In the 13th century it was captured by the Velasco family who built a wall around the town and erected a tower to protect it from the Salazars ’ one of the many constantly feuding families that lived in this region.

The main square lies at the heart of the town, named after Saint Ann following the construction of the convent of the same name. Built under the orders of Sancho Ortiz in the 15th century, it would later incorporate the community of the Conceptionist Franciscan nuns. Today it is the finest example of Mudejar art in the province of Burgos. Highlights include several outstanding buildings such as the Church of Villasana, originally known as La Asunción, located in the original settlement, and later replace by the Church of Nuestra Señora de los Altices.